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The science behind Epice Skincare products

Product Description

The first signs of aging skin typically begin with superficial wrinkles.  Therefore, it is understandable that anti-wrinkle ingredients play an important role in anti-aging products.  Over the last few years’ peptides have become an important part of the wrinkle-reducing products.  Epice’s proprietary ingredient (EPI) is an aqueous unpreserved glycerin based solution of a small peptide.  It stimulates the collagen synthesis in human fibroblasts, or in layman’s terms, it was developed to reduce any type of wrinkles.  Clinical trials have shown that this proprietary ingredient is capable of reducing and changing the type and aspect of wrinkles that add years to your appearance. 



Skin aging and in particular, chronic UV exposure, leads to degenerative changes in the skin characterized by distinct alterations in the composition of the dermal extra cellular matrix (ECM).  The consequences are manifold such as increased skin fragility, leather skin appearance and formation of wrinkles.  Collagen represents the main component of the ECM of the dermal connective tissue.  Thrombospondin I (TSP) is a multifunctional protein that activates the latent but biological inactive form of TGF-B (Tissue Growth Factor).  TGF-B is known as the key element in the synthesis of collagen.  TGF-B binds to a particular sequence in the TSP molecule.  This sequence is known as ARG-PHE-LYS.  A molecule able to activate TGF-B would therefore be the ideal product as an effective wrinkle-reducing molecule to accelerate new collagen production.  EPI is a patented innovative approach that is based on many years of experience in synthesizing peptides for the pharmaceutical industry.  EPI has a unique sequence to mimic the human body’s own mechanism to product collagen via TGF-B.  It actively compensates for any collagen deficit in the skin and makes the skin look younger.


Anti-wrinkle effect of EPI

Our study was performed on 60 volunteers.  EPI has been compared against placebo and against a reference substance.  Both products have been used at the recommended use level calculated for their active principle.  The study lasted 84 days with a twice-daily application.

Results showed significant and visible decrease in wrinkle depth.  The majority of the volunteers have noticed freshness and moisturizing sensation after application.  More than 60% of all volunteers reported a general modification of the skin and an improvement of the crow’s feet at the same time.  93% of the volunteers will continue of an EPI containing ingredient.


Clinical trials have shown that the active principle of EPI is capable of reducing and changing the type and aspect of wrinkles that add years to your appearance.  Try Epice Skincare products and experience the difference.

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